Signal from the longevity frontier
Short, sourced takes on the breakthroughs that matter — what happened, why it matters, and where the field goes next. Educational commentary, not medical advice.
Sinclair’s gut-health episode says eat to lower inflammation and support nutrient sensing. On 143 of 440 foods we scored, the anti-inflammatory and food-sensitivity lists disagree.
Read →The free browser tool behind the nutrition page — 440 foods, each carrying an independent histamine (SIGHI), lectin and net-carb score on a 0–3 scale, never averaged. On 143 of them the scales flatly disagree, and 52 are clean on both and still break ketosis.
Read →A review of a 2026 Nature Aging study from Barabási’s lab that maps aging’s hallmarks across the human protein network and flags already-approved drugs worth repurposing — validated against mouse and human trial data.
Read →Enzymes that clear molecular damage plus partial epigenetic reprogramming that resets the aging clock — how they combine, and a grounded look at how, by whom, and where they may first be delivered.
Read →A 2026 Nature Communications study reports an engineered enzyme that strips a major advanced glycation end-product out of aged human tissue — pushing 75-year-old aorta and skin back toward 30-year-old levels.
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